Deprotection of 4-Methoxybenzyloxycarbonyl Group withp-Toluenesulfonic Acid in Acetonitrile. Application to a Large-scale Preparation of 7-[D-2-Amino-2-(4-hydroxyphenyl)acetamido]cephalosporanic Acid
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چکیده
منابع مشابه
Application of 4-Chlorobutyryl Group as Amino Protective Group in the Synthesis of 7-(D-2-Amino-2-phenylacetamido)-3- -methyl-3-cephem-4-carboxylic Acid (Cephalexin)*
4-Chlorobutyryl group was used as amino protective group for n(-)-alpha-phenylglycine (I). N-Hydroxysuccinimide ester III was prepared in high yield but partly racemic. Reaction of III or IV with V afforded epimeric mixtures of N,0-protected cephalexins (VI), which can be separated by crystallisation. The 4-chlorobutyryl group in VII was removed under very mild conditions giving cephalexin (IX)...
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In the present research, 4, 4'-biphenol was used as a homogeneous mediator for determining cysteine (CySH) on a Glassy Carbon Electrode (GCE). To describe the electrochemical properties of 4,4'-biphenol and to examine its electrocatalytic impacts on cysteine oxidation, both Cyclic Voltammetry (CV) and Linear Sweep Voltammetry (LSV) were employed. Our findings revealed that 4,4'-biphenol could s...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1984
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.57.3333